Albert Gjedde

Current Positions:

Professor of Neurobiology and Pharmacology, Faculty of Health & Medical Sciences, U of Cph

Adjunct Professor, Department of Neurology, McGill University, Montreal, Quebec, Canada

Adjunct Professor, Dept of Radiology and Radiological Science, Johns Hopkins University, Baltimore

Past Positions:

1979 – 1981 Assistant Professor, Medical Physiology, University of Copenhagen, Copenhagen, Denmark

1981 – 1994 Associate Professor (tenure), Medical Physiology, University of Copenhagen

1986 – 1989 Associate Professor (tenure), Neurology and Neurosurgery, McGill University, Montréal

1989 – 1994 Director, McConnell Brain Imaging Centre, Montreal Neurological Institute, Canada

1989 – 1994 Professor (tenure) of Neurology and Neurosurgery, McGill University, Montréal, Canada

1994 – 2000 DMRC Professor of Brain Research, Aarhus University, Aarhus, Denmark

1994 – 2008 Head of Department, PET Center, Aarhus University Hospitals, Aarhus, Denmark

2000 – 2008 Professor of Medical Neurobiology, Aarhus University, Aarhus, Denmark

2001 – 2004 Director, DGF Centre of Functionally Integrative Neuroscience (CFIN), Aarhus University

2008 – 2014 Chair, Dept of Neuroscience and Pharmacology, Faculty Health & Medical Sciences, U of Cph

Research: Albert Gjedde’s research focuses on the relations between neuroplasticity and neurotransmission revealed by mapping radioligand binding and the neuroplastic changes of brain functions. The investigations explore the relation between energy metabolism and neurotransmission by recording the changes of energy metabolism and consciousness under pharmacological and other manipulations. Albert Gjedde uses PET to understand 1) the synthesis of radioligand and tracer molecules that match the neurotransmitter molecules and the behavior of these transmitters under different functional conditions of the brain, normal as well as pathological, and 2) the spatial and temporal relations among changes of cerebral blood flow, which is commonly used as a measure of brain work, and the cerebral oxygen consumption rate as the precise measure of this work.

Publication Statistics: PubMed lists 369 full-length peer-reviewed papers July 2015; with 20.929 citations and H-index 73 (Google scholar).

Distinctions: Fellow, Royal Society of Canada, American Association for the Advancement of Science, American College of Neuropsychopharmacology; Member, Academy of Europe, Norwegian Academy of Science and Letters.

Latest Original Peer-Reviewed First-Author Papers:

  • 1.Gjedde A, Aanerud J, Braendgaard H, Rodell AB. Blood-brain transfer of Pittsburgh compound B in humans. Front Aging Neurosci. 2013 Nov 7; 5: 70. doi: 10.3389/fnagi.2013.00070. eCollection 2013.
  • 2.Gjedde A, Aanerud J, Peterson E, Ashkanian M, Iversen P, Vafaee M, Møller A, Borghammer P. Variable ATP yields and uncoupling of oxygen consumption in human brain. Adv Exp Med Biol. 2011; 701: 243-8. doi: 10.1007/978-1-4419-7756-4_32.
  • 3.Gjedde A, Keiding S, Vilstrup H, Iversen P. No oxygen delivery limitation in hepatic encephalopathy. Metab Brain Dis. 2010 Mar; 25(1): 57-63. doi: 10.1007/s11011-010-9179-9. Epub 2010 Feb 25.
  • 4.Gjedde A, Kumakura Y, Cumming P, Linnet J, Møller A. Inverted-U-shaped correlation between dopamine receptor availability in striatum and sensation seeking. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8): 3870-5. doi: 10.1073/pnas.0912319107. Epub 2010 Feb 4.
  • 5.Gjedde A, Geday J. Deep brain stimulation reveals emotional impact processing in ventromedial prefrontal cortex. PLoS One. 2009 Dec 7; 4(12): e8120. doi: 10.1371/journal.pone.0008120.
  • 6.Gjedde A, Johannsen P, Cold GE, Ostergaard L. Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition. J Cereb Blood Flow Metab. 2005 Sep; 25(9): 1183-96.
  • 7.Gjedde A. Cerebral blood flow change in arterial hypoxemia is consistent with negligible oxygen tension in brain mitochondria. Neuroimage. 2002 Dec; 17(4): 1876-81.
  • 8.Gjedde A, Marrett S. Glycolysis in neurons, not astrocytes, delays oxidative metabolism of human visual cortex during sustained checkerboard stimulation in vivo. J Cereb Blood Flow Metab. 2001 Dec; 21(12): 1384-92.